Functional Changes in Tg P23h-1 Retinal Responses: 1 Differences between on and off Pathway
نویسندگان
چکیده
1 DIFFERENCES BETWEEN ON AND OFF PATHWAY 2 TRANSMISSION TO THE SUPERIOR COLLICULUS 3 4 5 James W. Fransen, Gobinda Pangeni, Ian S. Pyle, Maureen A. McCall 6 7 University of Louisville 8 1 Department of Anatomical Sciences and Neurobiology 9 2 Department of Ophthalmology & Visual Sciences 10 301 E. Muhammad Ali Blvd Room 420 11 Louisville, KY 40202 12 13 *Correspondence 14 Address: 301 E. Muhammad Ali Blvd, Louisville, KY 40202 15 Email:[email protected] 16 Phone: 502-852-3386 17 18
منابع مشابه
Functional changes in Tg P23H-1 rat retinal responses: differences between ON and OFF pathway transmission to the superior colliculus.
The morphological consequences of retinal photoreceptor degeneration are well documented. Much less is known about changes in visual function during degeneration and whether central visual structures directly reflect changes in retinal ganglion cell (RGC) function. To address this, we compared changes in visual function of RGCs and cells in the superior colliculus (SC) in transgenic (Tg) P23H-1...
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PURPOSE We evaluated the photoreceptor response of pigmented P23H and normal pigmented Long Evans (LE) rats over time using functional tests in variable lighting conditions. METHODS Pigmented P23H rats were studied by optomotor testing and electroretinogram (ERG) recordings at P30, P150, and P240. Pigmented LE rats were used as a normal wild-type control. Stimuli were modified with colored fi...
متن کاملChanges in physiological properties of rat ganglion cells during retinal degeneration.
Retinitis pigmentosa (RP) is a leading cause of degenerative vision loss, yet its progressive effects on visual signals transmitted from the retina to the brain are not well understood. The transgenic P23H rat is a valuable model of human autosomal dominant RP, exhibiting extensive similarities to the human disease pathology, time course, and electrophysiology. In this study, we examined the ph...
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PURPOSE Neural ectopic rewiring in retinal degeneration such as retinitis pigmentosa (RP) may form functional synapses between cones and rod bipolar cells that cause atypical signal processing. In this study, the multifocal electroretinograms (mfERGs) of a large animal model of RP, the rhodopsin P347L transgenic (Tg) pig, were measured to examine the sources and nature of altered signal process...
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